30male Sprague Dawley rats weighing 200±5^(gm) were used. They were divided into 1 day group, 3 day group, 5 day group, 10 day group, 20 day group, and control group. To all experimental rats 20% alcohol, 5^(mg) per kg body weight, was orally administered. This experiment was studied to evaluate the effect of alcohol on the acinar cells of parotid gland of rats.
Thefollo wing results were obtained ;
1. In the acinar cells of the control rats, rER was clouded in basal and peripheral
portion of nucleus, and a lot of secretory granules were showed in apical portion.
2. As compared with the control group, there were no observable change of the ultrastructure in the 1 day group.
3. In the 3 day group, rough endoplasmic reticulum(rER) showed swelling and large secretory granules were formed in the cytoplasm.
4. In the 5 day group, rER showed the irregular arrangement with swelling. ´Vlitocr hondria showed the swelling and slight variation. Lysosomes vere observed.
5. In the 10 day group, many parts of rER in the cytoplasm showed swelling and were decreased. Free ribosomes and rER showed remarkable decrease in number and mitochondria was swollen or destructed.
6. In the 20 day group, rER showed the irregular arrangement and destruction. Electron-lucent vacuoles were formed in the cytoplasm and mitochondria showed destruction.
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